Is it safe to combine CBD with medication?

Is it safe to combine CBD with medication? 

CBD is not an ingredient that can be used with all medications. Interactions between CBD and the medications you take may affect the way your medications are metabolized and may also make them less effective.

Almost all components of the body are broken down by enzymes and metabolized through various pathways. Drugs are metabolized by CYP450 enzymes, and CYP450s can be further divided into the following types:

- CYP1A2

- CYP2D6

- CYP2C9

- CYP2C19

- CYP3A4

Each can be metabolized differently in terms of components and drugs, affecting their effectiveness and elimination.

For example, let's say you take three drugs A, B, and C, all of which are necessary for CYP1A2 metabolism, at once. This means that CYP1A2 may be insufficient in the body, and even if drug A can be metabolized, drug B and C cannot be metabolized, so the effect may not appear, or conversely, the drug may accumulate in the body indefinitely.

Metabolism of CBD requires exactly the CYP1A2 enzyme mentioned above. This means that when used in combination with drugs that require the same enzyme, either one may be less effective or may remain in the body.

There are many drugs that require CYP1A2, and it is said that about 60% of the drugs currently available in hospitals require it.


【Can't CBD and medications be taken together? 】

As I introduced above, it is not recommended to take CBD and medicine at the same time. However, it may be used in combination with chemicals that do not require CYP1A2.

In addition, it is said that even drugs that require the enzyme can be ingested by shifting the timing of drinking, leading to reduction of side effects. For example, painkillers that are often taken due to chronic pain, migraines, and periodic pain peculiar to women. This seems to be highly dependent and less effective when ingested habitually. Alternating intakes with CBD or using CBD when symptoms are relatively mild can reduce side effects.

If you want to use a combination of CBD and medicine, please take it at a staggered time or consult a doctor to incorporate it safely and securely.